Super Sledge - 2.67

Most popular two-handed weapon

Reduces enemy resistances by 50%, which translates to around 28.9% effective damage increase (multiplicative) for noncritical hits for most cases (Armor effectiveness depends on the ratio of damage/armor with a minimum cap - full armor penetration - at 6.66 - no kidding).
Increases melee DPS by 40%. Doesn't work on 'rotating' melee weapons (Ripper, Mr Handy Buzz Blade).
Breaks 50% slower

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Disclaimer

The game is often being adjusted under the hood, and to have precise results, its necessary to periodically retest everything. If there's something that you think should be retested, or you want to share:

Notice for Console Players

The system has been build based on extensive market research ON PC ecosystem - and hence is reflecting console reality less precisely. Remember, this is just a price approximation based on global PC market.